American Board of Dental Examiners (ADEX) Dental Hygiene Licensing Examination 2025 – 400 Free Practice Questions to Pass the Exam

Dentinogenesis imperfecta Type 1 is genetically associated with osteogenesis imperfecta, also known as "brittle bone disease." Both conditions arise from mutations in the genes responsible for collagen production, particularly the COL1A1 and COL1A2 genes. These genes are essential for the integrity of connective tissues, including bone and dentin.

In dentinogenesis imperfecta Type 1, the quality and structure of dentin are compromised, leading to characteristic dental manifestations such as discolored teeth, fragile enamel, and a propensity for dental fractures. Similarly, osteogenesis imperfecta leads to weakened bones, making them more susceptible to fractures. The shared underlying collagen abnormalities explain the close relationship between the two conditions.

The other conditions listed do not share the same genetic basis as dentinogenesis imperfecta Type 1. Osteoporosis, for instance, is generally a metabolic bone disorder associated with decreased bone density, rather than a genetic disorder like osteogenesis imperfecta. Amelogenesis imperfecta, on the other hand, is related specifically to enamel formation and does not involve dentin changes. Enamel dysplasia refers to abnormalities in enamel formation and is not directly connected to the underlying collagen issues characterizing dentinogenesis imperfecta Type 1.